N-Methyl-D-Aspartate Receptor Activation Interacts with Electrical High Frequency Stimulation in the Rat Caudate Nucleus in vitro and in vivo
نویسندگان
چکیده
Electrical high frequency stimulation is used as treatment for motoricas well as psychomotoric disorders in various regions of the brain. The biochemical mechanisms of the action of high frequency stimulation underlying the effective results are unclear. Previous studies have demonstrated that electrical 130 Hz stimulation was capable of increasing local γaminobutyric acid outflow in the rat caudate nucleus when neuronal pre-activation was present. In the present study, the local effect of electrical high frequency stimulation on γ-aminobutyric was reviewed under conditions of N-methyl-Daspartate receptor activation. Using in vitro superfusion experiments with tissue slices from the rat caudate nucleus, and colocalized in vivo microdialysis and electrical 130 Hz stimulation of the caudate nucleus in awake and freely moving rats, we can conclude that N-methyl-D-aspartate receptor activation was able to modulate γ-aminobutyric acid outflow induced by electrical high frequency stimulation.
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